Ebook
Ebook Neurologi : Bradleys Neurology In Clinical Practice
Neurology in Clinical Practice is a practical textbook of neurology that covers all the clinical neurosciences and provides not only a description of neurological diseases and their pathophysiology but also a practical approach to their diagnosis and management. In the preface to the 1991 first edition of this book, we forecast that major technological and research advances would soon reveal the underlying cause and potential treatment of an ever-increasing number of neurological diseases. The near quarter century since that prediction has been filled with the excitement of new discoveries resulting from the blossoming of neurosciences. Genetics and molecular biology have revolutionized our understanding of neurological disorders; targeted therapies that treat the basis of disease have improved outcomes and changed the course of many neurological diseases such as multiple sclerosis and other neuroimmune disorders and tumors associated with tuberous sclerosis. Advances in neuroimaging now enable the precise identification of functional regions and fine neuroanatomy of the human brain in health and disease. The important and challenging problem of neuroprotection is being addressed in both neurodegenerative disorders and acute injuries to the nervous system, such as stroke, hypoxic brain injury, and trauma. In line with this effort, basic science progress in areas of neuroplasticity and neural repair is yielding important results that should translate into clinical utility in the near future. When the first edition of this textbook was published, there was essentially no effective means of treating acute ischemic stroke. Today we have numerous opportunities to help such patients, and a campaign has begun to educate the general public about the urgency of seeking treatment when stroke symptoms occur. These and other advances have changed neurology to a field in which interventions are increasingly improving the outcomes of disorders previously considered to be untreatable. The advent of teleneurology is also beginning to provide treatment for patients who lack access to neurological specialists or whose problems are too complicated for routine management in the community. Teleneurology consults are beginning to be provided nationwide across all subspecialties of our discipline, with a particular emphasis on patients who need intraoperative monitoring, critical care neurology, and stroke interventions. To the benefit of patients, clinical neuroscience has partnered with engineering. Neuromodulation has become an important part of clinical therapy for patients with movement disorders and has applications in pain management and seizure control. Along these same lines, brain-controlled devices will soon help provide assistance to individuals whose mobility or communication skills are compromised. Recent advances in optogenetics have led to development of techniques that allow exploration and manipulation of neural circuitry, which may have therapeutic applications in a variety of neurologic disorders. Finally, a search for biomarkers that reliably identify a preclinical state and track progression of disease is a promising goal in many neurodegenerative disorders. Age-related neurodegenerative diseases, such as Alzheimer disease and Parkinson disease, are increasingly prevalent and represent a growing health and socioeconomic burden. The costs in terms of
suffering Neurology in Clinical Practice is a practical textbook of neurology that covers all the clinical neurosciences and provides not only a description of neurological diseases and their pathophysiology but also a practical approach to their diagnosis and management. In the preface to the 1991 first edition of this book, we forecast that major technological and research advances would soon reveal the underlying cause and potential treatment of an ever-increasing number of neurological diseases. The near quarter century since that prediction has been filled with the excitement of new discoveries resulting from the blossoming of neurosciences. Genetics and molecular biology have revolutionized our understanding of neurological disorders; targeted therapies that treat the basis of disease have improved outcomes and changed the course of many neurological diseases such as multiple sclerosis and other neuroimmune disorders and tumors associated with tuberous sclerosis. Advances in neuroimaging now enable the precise identification of functional regions and fine neuroanatomy of the human brain in health and disease. The important and challenging problem of neuroprotection is being addressed in both neurodegenerative disorders and acute injuries to the nervous system, such as stroke, hypoxic brain injury, and trauma. In line with this effort, basic science progress in areas of neuroplasticity and neural repair is yielding important results that should translate into clinical utility in the near future. When the first edition of this textbook was published, there was essentially no effective means of treating acute ischemic stroke. Today we have numerous opportunities to help such patients, and a campaign has begun to educate the general public about the urgency of seeking treatment when stroke symptoms occur. These and other advances have changed neurology to a field in which interventions are increasingly improving the outcomes of disorders previously considered to be untreatable. The advent of teleneurology is also beginning to provide treatment for patients who lack access to neurological specialists or whose problems are too complicated for routine management in the community. Teleneurology consults are beginning to be provided nationwide across all subspecialties of our discipline, with a particular emphasis on patients who need intraoperative monitoring, critical care neurology, and stroke interventions. To the benefit of patients, clinical neuroscience has partnered with engineering. Neuromodulation has become an important part of clinical therapy for patients with movement disorders and has applications in pain management and seizure control. Along these same lines, brain-controlled devices will soon help provide assistance to individuals whose mobility or communication skills are compromised. Recent advances in optogenetics have led to development of techniques that allow exploration and manipulation of neural circuitry, which may have therapeutic applications in a variety of neurologic disorders. Finally, a search for biomarkers that reliably identify a preclinical state and track progression of disease is a promising goal in many neurodegenerative disorders. Age-related neurodegenerative diseases, such as Alzheimer disease and Parkinson disease, are increasingly prevalent and represent a growing health and socioeconomic burden. The costs in terms of
suffering
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